Instaflex Joint Support Reviews

instaflex joint support

“The #1 selling joint supplement in GNC stores nationwide” is also the premier product from nutrition and wellness company Instaflex.

Instaflex Joint Support contains an exclusive formula to relieve joint pain.

Because Instaflex Joint Support is sold from major supplement distributors and popular among users, I wanted to figure out what makes Instaflex Joint Support such a favored product.

What’s Inside?

Instaflex Joint Support has 8 ingredients to promote healthy, active lifestyles.

Glucosamine Sulfate

Glucosamine sulfate is a fluid that cushions joints. Without glucosamine sulfate, bone friction causes pain and stiffness.

Studies show glucosamine sulfate reduces joint-space loss.[1] Instaflex Joint Support has the recommended dose of 1,500 mg a day.


Methylsulfonylmethane (MSM) forms connective tissue in joints. Though testing is sparse, one early study showed MSM relieved pain and improved physical function in participants with osteoarthritis.[2]

The 500 mg dose in Instaflex Joint Support is lower than the suggest amount of 500 mg 3 times daily, but will likely have some effect.

White Willow Bark Extract

White willow bark has been used historically to reduce pain due to its aspirin-like chemical salicin. One study shows participants experienced moderate pain relief from 240 mg white willow bark daily.[3]

Instaflex Joint Support has 250 mg white willow bark extract.

Ginger Root Concentrate

Ginger reduces inflammation, and 75% of osteoarthritis patients experienced decreased swelling in one study.[4]

Instaflex Joint Support has 250 mg ginger root concentrate. No effective dose has been determined through scientific testing.

Boswellia Serrata Extract

Also called Indian frankincense and blessed thistle, boswellia improves the range of motion in joints as it reduces swelling. One study showed boswellia extract effectively relieves knee pain.[5]

There is no recommended dose for boswellia serrata extract, though 125 mg is included in Instaflex Joint Support.

Turmeric Root Extract

Turmeric is an anti-inflammatory herb. Unfortunately, I could only find animal studies supporting its use for joint pain. However, arthritis was reduced in mice taking turmeric.[6]

Instaflex Joint Support has a small 50 mg dose, which is low compared to the recommended 400 and 600 mg, 3 times a day.[7]

Cayenne 40m H.U.

Cayenne stops pain messages from reaching the brain by reducing certain chemicals. In one study, topically applied cayenne significantly decrease pain in subjects.[8]

However, I could not find information examining if the same results occur when ingested, as found in 50 mg in Instaflex Joint Support.

Hyaluronic Acid

Hyaluronic acid is a natural cushion and lubricant for joints. Testing supports its use, but only when injected directly into the joint.[9]

The 4 mg in Instaflex Joint Support seems low, and I’m unsure if it produces the same results as the study.

Are There Side Effects?

The most common side effects occurred as a result of allergic reactions. All of the ingredients in Instaflex Joint Support may cause digestive problems; the most common are nausea, vomiting, and heartburn.

Recommended Use

Instaflex Joint Support comes in bottles of 90 capsules. Take 3 capsules a day with water.

The best results, advertisers claim, come when combining Instaflex Joint Support with diet and exercise.

Purchasing Instaflex Joint Support

Instaflex Joint Support is sold online through multiple retailers. has the most secure, 30 day money-back guarantee.

Is It Worth It?

There is a lot going for Instaflex Joint Support. The ingredients seem decent, and you can buy it from many reputable retailers. However, the ingredients are all known to cause digestive discomfort, and it’s expensive when compared to other similar supplements. If you’re interested, I suggest going to a third party side such as to find a reduced price.

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[1] Reginster, J., R. Deroisy, L. Rovati, R. Lee, E. Lejeune, O. Bruyere, G. Giacovelli, Y. Henrotin, J. Dacre, and C. Gossett. "Long-term Effects of Glucosamine Sulphate on Osteoarthritis Progression: A Randomised, Placebo-controlled Clinical Trial." The Lancet 357.9252 (2001): 251-56. Web.

[2] Kim, L., L. Axelrod, P. Howard, N. Buratovich, and R. Waters. "Efficacy of Methylsulfonylmethane (MSM) in Osteoarthritis Pain of the Knee: A Pilot Clinical Trial1, 2." Osteoarthritis and Cartilage 14.3 (2006): 286-94. Web.

[3] Schmid, B., Lüdtke, R., Selbmann, H.-K., Kötter, I., Tschirdewahn, B., Schaffner, W. and Heide, L. (2001), Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial. Phytother. Res., 15: 344–350. doi: 10.1002/ptr.981

[4] Srivastava, K.C., and T. Mustafa. "Ginger (Zingiber Officinale) in Rheumatism and Musculoskeletal Disorders." Medical Hypotheses 39.4 (1992): 342-48. Web.

[5] Kimmatkar, N. "Efficacy and Tolerability of Extract in Treatment of Osteoarthritis of Knee ? A Randomized Double Blind Placebo Controlled Trial." Phytomedicine 10.1 (2003): 3-7. Web.

[6] Funk, Janet L., Janice N. Oyarzo, Jennifer B. Frye, Guanjie Chen, R. Clark Lantz, Shivanand D. Jolad, Aniko M. Sólyom, and Barbara N. Timmermann. "Turmeric Extracts Containing Curcuminoids Prevent Experimental Rheumatoid Arthritis." Journal of Natural Products 69.3 (2006): 351-55. Web.

[7] “Turmeric.” University of Maryland Medical Center. Available from:

[8] Deal, CL, TJ Schnitzer, E. Lipstein, JR Seibold, RM Stevens, MD Levy, D. Albert, and F. Renold. "Treatment of Arthritis with Topical Capsaicin: A Double-blind Trial." Clinical Therapeutics (n.d.): n. pag. Web.

[9] Swann, D. A., E. L. Radin, M. Nazimiec, P. A. Weisser, N. Curran, and G. Lewinnek. "Role of Hyaluronic Acid in Joint Lubrication." Annals of the Rheumatic Diseases 33.4 (1974): 318-26. Web.